WHAT IT DOES A MEDICAL FOOD FOR THE DIETARY MANAGEMENT OF MODERATE TO SEVERE IMPAIRED GI FUNCTION Physicians' Elemental Diet is a medical food designed for the dietary management of moderate to severe impaired gastrointestinal (GI) function, including irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and small intestinal bacterial overgrowth (SIBO). Physicians' Elemental Diet is designed to maintain nutritional sustenance as the sole source of nutrition for patients under medical supervision. HOW IT WORKS CLINICAL EVIDENCE OF ELEMENTAL DIETS Published clinical studies have shown that elemental diets are effective for the nutritional management of patients with moderate to severe impaired GI function.^1,2 In a clinical study of 93 patients with IBS and abnormal lactulose breath test scores, 80% of those who received an elemental diet had normalized test results with an associated improvement in clinical symptoms after 14 days.³ By 21 days, 85% of those patients saw improvement. Elemental diets can also be effective for managing IBD. In a controlled clinical study, 28 patients with active Crohn's disease received an elemental diet for 4 weeks with no other food or medication. Clinical remission was achieved in 71% of patients. REDUCES THE WORK OF DIGESTION, ALLOWING THE GUT TO REST AND RECUPERATE Physicians' Elemental Diet contains a balanced blend of macronutrients fortified with essential micronutrients and electrolytes to assure comprehensive support as the sole source of nutritional intake for limited periods. All the ingredients are in their simplest form for easy digestion and the product was designed with a well-tolerated flavor to encourage patient commitment to the diet. This hypoallergenic formula contains no intact proteins, polypeptides, corn, gluten, soy, or dairy.

WHAT IT DOES METABOLIC SUPPORT* Berberine offers metabolic support for glucose and lipid metabolism.* It also supports healthy blood sugar and insulin levels already within a normal range.* HOW IT WORKS Clinical studies demonstrate that berberine supports healthy lipid metabolism and cholesterol homeostasis.*^1-6 Berberine can activate an important metabolic enzyme known as adenosine monophosphate-activated protein kinase (AMPK), a central regulator of cellular energy homeostasis.* Mechanistic research in vitro and in vivo suggests that berberine can decrease cholesterol and triglyceride synthesis by activating AMPK.^7-9& In addition to supporting lipid metabolism, berberine supports healthy glucose metabolism and blood sugar management already within a normal range.*^2-5 Mechanistic research in vitro suggests that berberine can support healthy glucose regulation through promoting glucose uptake in cells via GLUT4 translocation.⁷

B-VITAMINS PLAY ESSENTIAL ROLES IN MANY FUNCTIONS OF THE BODY Optimal folate and B vitamin intakes are associated with healthy neurological function as well as cardiovascular support.*^1,2 Each B-vitamin exists in multiple forms, often referred to as vitamers. Active forms of vitamers are those that can be directly utilized by the body immediately. Active B-Complex features a balanced, hypoallergenic blend containing the active forms of Vitamins B2, B6, B12, as well as Quatrefolic®-branded methylfolate (the bioactive form of folic acid).

HOW IT WORKS

B-vitamins play essential roles in many functions of the body. Vitamin B1 (as Thiamin) and Vitamin B2 (Riboflavin as riboflavin-5'-phosphate) serve as coenzymes essential for cell function, growth and energy production.*¹ Vitamin B6 (as pyridoxal-5-phosphate and pyridoxine HCl) has an essential role in the synthesis of neurotransmitters, including serotonin, dopamine and gamma-aminobutyric acid (GABA).*³ Folate [as Quatrefolic® brand (6S)-5-Methyltetrahydrofolate, glucosamine salt] has essential roles in nervous system and immune system function.*^1,4 Vitamin B12 (as methylcobalamin) is essential for nervous system function, playing particular roles in myelin synthesis and nerve metabolism.

The ingredients in Cortisol Manager support healthy cortisol levels.* Cortisol is one of the most important hormones involved in the adaptation process. By supporting balanced cortisol and a healthy stress response, Cortisol Manager also promotes relaxation to support restful sleep.* THE ROLE OF CORTISOL IN TIMES OF STRESS Cortisol is a hormone produced in the adrenal cortex that is released during times of stress. Variations in cortisol secretion can indicate how well the body is coping with stress. Cortisol homeostasis is typically characterized by peak secretion during the early morning hours with a gradual decline throughout the day. Because of its central role as a key stress hormone, cortisol is often thought of as a bridge between stress and its health impact. WITH HERBAL INGREDIENTS The ingredients in Cortisol Manager help support a balanced, adaptive cortisol response to stress.* Cortisol Manager contains a stress-reducing proprietary blend of Sensoril® brand ashwagandha (Withania somnifera) and Suntheanine™ brand L-theanine.* A proprietary blend of Magnolia (Magnolia officinalis) and epimedium (Epimedium koreanum), as well as phosphatidylserine from soy lecithin are included in Cortisol Manager. A 2008 placebo-controlled clinical trial showed that Sensoril® ashwagandha significantly reduced serum cortisol levels and helped manage stress compared to placebo, in subjects experiencing higher levels of stress.*¹ A 2018 placebo-controlled clinical trial showed that a single intake of Suntheanine™ L-theanine significantly increased alpha brain wave activity in subjects compared to their placebo counterparts.*² Alpha brain wave activity is associated with a more relaxed mental state.*² Together the ingredients in Cortisol Manager help support relaxation, to promote restful sleep.* They also help stabilize the stress hormone cortisol to further support a healthy stress response.*