B-VITAMINS PLAY ESSENTIAL ROLES IN MANY FUNCTIONS OF THE BODY Optimal folate and B vitamin intakes are associated with healthy neurological function as well as cardiovascular support.*^1,2 Each B-vitamin exists in multiple forms, often referred to as vitamers. Active forms of vitamers are those that can be directly utilized by the body immediately. Active B-Complex features a balanced, hypoallergenic blend containing the active forms of Vitamins B2, B6, B12, as well as Quatrefolic®-branded methylfolate (the bioactive form of folic acid).

HOW IT WORKS

B-vitamins play essential roles in many functions of the body. Vitamin B1 (as Thiamin) and Vitamin B2 (Riboflavin as riboflavin-5'-phosphate) serve as coenzymes essential for cell function, growth and energy production.*¹ Vitamin B6 (as pyridoxal-5-phosphate and pyridoxine HCl) has an essential role in the synthesis of neurotransmitters, including serotonin, dopamine and gamma-aminobutyric acid (GABA).*³ Folate [as Quatrefolic® brand (6S)-5-Methyltetrahydrofolate, glucosamine salt] has essential roles in nervous system and immune system function.*^1,4 Vitamin B12 (as methylcobalamin) is essential for nervous system function, playing particular roles in myelin synthesis and nerve metabolism.

The ingredients in Cortisol Manager support healthy cortisol levels.* Cortisol is one of the most important hormones involved in the adaptation process. By supporting balanced cortisol and a healthy stress response, Cortisol Manager also promotes relaxation to support restful sleep.* THE ROLE OF CORTISOL IN TIMES OF STRESS Cortisol is a hormone produced in the adrenal cortex that is released during times of stress. Variations in cortisol secretion can indicate how well the body is coping with stress. Cortisol homeostasis is typically characterized by peak secretion during the early morning hours with a gradual decline throughout the day. Because of its central role as a key stress hormone, cortisol is often thought of as a bridge between stress and its health impact. WITH HERBAL INGREDIENTS The ingredients in Cortisol Manager help support a balanced, adaptive cortisol response to stress.* Cortisol Manager contains a stress-reducing proprietary blend of Sensoril® brand ashwagandha (Withania somnifera) and Suntheanine™ brand L-theanine.* A proprietary blend of Magnolia (Magnolia officinalis) and epimedium (Epimedium koreanum), as well as phosphatidylserine from soy lecithin are included in Cortisol Manager. A 2008 placebo-controlled clinical trial showed that Sensoril® ashwagandha significantly reduced serum cortisol levels and helped manage stress compared to placebo, in subjects experiencing higher levels of stress.*¹ A 2018 placebo-controlled clinical trial showed that a single intake of Suntheanine™ L-theanine significantly increased alpha brain wave activity in subjects compared to their placebo counterparts.*² Alpha brain wave activity is associated with a more relaxed mental state.*² Together the ingredients in Cortisol Manager help support relaxation, to promote restful sleep.* They also help stabilize the stress hormone cortisol to further support a healthy stress response.*

WHAT IT IS MULTI-NUTRIENT NUTRITIONAL SUPPLEMENT FOR MITOCHONDRIAL HEALTH* A unique combination of N-acetyl cysteine, acetyl L-carnitine, alpha-lipoic acid and other key nutrients that support mitochondrial functioning, based on the many years of clinical practice and ongoing research studies led by Dr. Jon Kaiser.* HOW IT WORKS SUPPORTS MITOCHONDRIAL FUNCTION* All cells, with the exception of red blood cells, contain mitochondria, organelles that produce adenosine triphosphate (ATP), the cellular "energy currency," from adenosine diphosphate (ADP). In addition, mitochondria are involved in many other processes within the body such as cell signaling and regulation of cellular metabolism. Mitochondrial energy metabolism is a critical part of cellular health and function. Mitochondrial function depends on quenching of free radicals produced during normal electron transport chain (ETC) activity, integrity of mitochondrial cell membranes and the transport of critical metabolites, such as fatty acids, into the mitochondria. One approach to supporting mitochondrial function is the provision of micronutrients and antioxidants that support these mechanisms.* K-PAX MitoNutrients is a unique combination of N-acetyl cysteine, acetyl L-carnitine, alpha-lipoic acid and other key nutrients that support mitochondrial functioning, based on the many years of clinical practice and ongoing research studies led by Dr. Kaiser.*