There has been significant research on the cardiovascular benefits of L-arginine – the primary ingredient in Perfusia-SR – for supporting vascular health and blood flow.* One of L-arginine’s most important roles is as a biological precursor of nitric oxide.* The vascular endothelium (the lining of the arteries) creates nitric oxide from L-arginine, resulting primarily in blood vessel relaxation.* This property is important to maintaining good vascular health, heart health, reproductive health, wound healing, and protection against oxidative damage.* L-arginine also promotes increased work capacity during exercise, supports lean muscle mass, and helps erections occur in the normal course of intimacy.* Perfusia-SR is provided in a sustained-release formula to maintain an optimal level of L-arginine over 24 hours with suggested twice-daily use.* L-arginine is a semi-essential amino acid involved in multiple areas of human physiology and metabolism.* It significantly affects endocrine function and helps regulate the release of neurotransmitter chemicals, insulin, glucagon (which has the opposite effect of insulin; i.e., it raises blood sugar), and growth hormone.* However, one of L-arginine’s most compelling contributions to human physiology is its role as a biological precursor of nitric oxide.* The vascular endothelium (the lining of the arteries) creates nitric oxide from L-arginine, resulting primarily in blood vessel relaxation.* This property is important to maintaining good vascular health, heart health, reproductive health, and protection against oxidative damage.* Maintaining the natural and healthy function of the vascular endothelium depends on an adequate supply of L-arginine being available to these cells.* Without adequate L-arginine (and subsequently, nitric oxide) available to the vascular endothelial cells, arteries might not optimally dilate, which can result in less than optimal blood flow to the organs and extremities.* A recent study demonstrated improvements in blood flow after Perfusia-SR supplementation in individuals who had less than optimum heart health.* In another study, Perfusia-SR was given to 29 healthy volunteers for one week and significant support for a healthy cardiovascular system was observed.* Studies on Perfusia-SR show increased blood flow to the heart muscle and the extremities, maintenance of already normal blood pressure, and improved vascular elasticity.* In a large, double-blind clinical trial that observed male reproductive health issues, 1.6 grams of L-arginine given daily for six weeks resulted in improvement in reproductive health in those men who had low nitric oxide metabolism.* Like most amino acids, L-arginine functions as a building block for proteins; however, its presence also appears to support wound healing.* Numerous studies show L-arginine supplementation benefits wound healing time and the strength of the tissues in and around the wound during the healing phase.