Indole-3-Carbinol (60 caps) by Thorne

Cruciferous vegetables, including broccoli, cauliflower, Brussels sprouts, and cabbage, contain a compound called indole-3-carbinol (I3C).* As a nutritional supplement, I3C provides key nutritional support for the liver’s detoxification of estrogens, thus playing an important role in supporting female reproductive health.* A large portion of I3C is converted to diindolylmethane (DIM), the substance believed to be the primary contributor to I3C’s beneficial properties. DIM has been shown to selectively bind to estrogen receptors and might act as an estrogen antagonist.*

In the liver, I3C promotes the metabolism of estrogen and increases the ratio of 2-hydroxy estrogen to 16-hydroxy estrogen.* The 2-hydroxy estrogens, which are less active than the 16-hydroxy estrogens, are generally eliminated more quickly from the body. One study found postmenopausal women who had the most favorable 2:16-hydroxy estrogen ratio were most likely to maintain good female health.* Studies have examined the efficacy, safety, and optimal supplementation of I3C. A 12-week trial conducted on 17 women found a 66-percent increase in the 2:16-hydroxy estrogen ratio with administration of 400 mg of I3C daily.*

*This product is not intended to diagnose, treat or cure any illness or disease. The content and recommendations contained on this website have not been reviewed by the U.S. Food and Drug Administration (FDA) and are solely the opinion of the authors. Content contained on this website is not a substitute for professional medical advice, diagnosis or treatment. Never increase, reduce or discontinue any medication or treatment without first consulting your doctor.