During times of acute stress, the hypothalamic-pituitary-adrenal (HPA) axis is over-stimulated and needs help re-balancing. The over-production of cortisol and other stress hormones is typical for individuals with HPA axis overload. Adrenal Calm is formulated to help respond to HPA axis overload by reducing cortisol levels and limiting the negative impact of acute adrenal stress.

Nattokinase is an enzyme extracted from natto, a soy based dietary staple in Japan believed to be a major contributing factor behind the country's record low rate of heart disease.